1982 48 Hrs. Reggie Hammond İlk Rolü
1983 Trading Places Billy Ray Valentine
1983 Eddie Murphy Delirous Kendisi Stand Up
1984 Best Defense Teğmen T.M. Landry
1984 Beverly Hills Cop Det. Axel Foley İlk Şöhreti
1986 The Golden Child Chandler Jarrell İlk Fantastik filmi
1987 Beverly Hills Cop II Det. Axel Foley
1987 Eddie Murphy Raw Kendisi Stand Up
1988 Coming to America Prince Akeem/Clarence/Randy Watson/Saul Ayrıca yapımcı ve senarist
1989 What's Alan Watching? (TV) Protestocu/James Brown İlk Televizyon filmi, ayrıca yapımcı
1989 Harlem Nights Quick İlk yönetmenliği
1990 Another 48 Hrs. Reggie Hammond
1992 Boomerang Marcus Graham
1992 The Distinguished Gentleman Thomas Jefferson Johnson
1993 Dangerous: The Short Films (V) Pharaoh Arşivden sahne-Michael Jackson'un Remember The Time Klibinden
1994 Beverly Hills Cop III Det. Axel Foley
1995 Vampire in Brooklyn Maximillian/Preacher Pauly/Guido
1996 Çatlak Profesör Profesör Sherman Klump/Buddy Love/Lance Perkins/Cletus Klump/Anna Pearl Jensen Klump/Ida Mae Jensen/Ernie Klump, Murphy'nin tekrar dönüşü niteliğinde bir film
1997 Metro Scott Roper
1998 Mulan Mushu Seslendirme
1998 Doctor Dolittle Dr. John Dolittle
1998 Holy Man G
1999 Life Rayford Gibson
1999 Çatlak Yönetmen (Bowfinger) Kit Ramsey/Jeffernson 'Jiff' Ramsey
2000 Çatlak Profesör 2 Sherman Klump/Buddy Love/Lance Perkins/Cletus Klump/Anna Pearl Jensen Klump/Ida Mae Jensen/Ernie Klump
2001 Shrek Eşek Seslendirme
2001 Dr. Dolittle 2 Dr. John Dolittle
2002 Showtime Trey Sellers
2002 The Adventures of Pluto Nash Pluto Nash
2002 I Spy Kelly Robinson
2003 Daddy Day Care Charlie Hinton
2003 Shrek 3-D Donkey Seslendirme,Dvd Extra
2003 The Haunted Mansion Jim Evers
2004 Shrek 2 Eşek Seslendirme
2004 Far Far Away Idol Eşek Seslendirme
2006 Dreamgirls James 'Thunder' Early İlk ve tek Oscar adaylığı
2007 Norbit Norbit/Rasputia/Bay Wong
2007 Shrek the Third Eşek Seslendirme
2008 Meet Dave Starship Dave (Spacecraft), Captain
2009 NowhereLand Evan Danielson
A Thousand Words Jack McCall
2010 Shrek Goes Fourth Donkey (seslendime)
Beverly Hills Cop IV Det. Axel Foley
2011 Kule Soygunu Darnell ('Slide')
2012 Kelimeler Yetmez Jack McCall
2016 Mr. Church Henry Church